Expression and transposition of the Suppressor‐mutator (Spm) transposon of maize are controlled by interacting epigenetic and autoregulatory mechanisms. Methylation of critical element sequences prevents both transcription and transposition, heritably inactivating the element. The promoter, comprising the terminal 0.2 kb of the element, and a 0.35‐kb, highly GC‐rich, downstream sequence are the methylation target sequences. The element encodes two proteins necessary for transposition, TnpA and TnpD. There are multiple TnpA binding sites, both in the 5′ terminal promoter region and at the (...) element's 3′ end. In addition to its role in transposition, TnpA is both a positive and a negative regulator of transcription. TnpA represses the element's promoter when it is not methylated. When the element is inactive and its promoter methylated, TnpA activates the methylated promoter and facilitates both its transient and heritable demethylation. (shrink)

Information about the structure, function and regulation of the maize Suppressormutator (Spm) transposable element has emerged from the genetic and molecular characterization of both deletion mutations and an unconventional type of reversible genetic change (epimutation). The element is subject to an epigenetic mechanism that can either stably inactivate it or specify one of a variety of heritable programs of differential element expression in development. The essay explores the relationship between the Spm element's epigenetic developmental programming mechanism and the determinative events (...) central to plant development and differentiation. (shrink)

We discuss the thesis formulated by Hintikka that certain natural language sentences require non-linear quantification to express their meaning. We investigate sentences with combinations of quantifiers similar to Hintikka's examples and propose a novel alternative reading expressible by linear formulae. This interpretation is based on linguistic and logical observations. We report on our experiments showing that people tend to interpret sentences similar to Hintikka sentence in a way consistent with our interpretation.

Next SectionWe discuss the thesis formulated by Hintikka (1973) that certain natural language sentences require non-linear quantification to express their meaning. We investigate sentences with combinations of quantifiers similar to Hintikka's examples and propose a novel alternative reading expressible by linear formulae. This interpretation is based on linguistic and logical observations. We report on our experiments showing that people tend to interpret sentences similar to Hintikka sentence in a way consistent with our interpretation.

The paper focuses on the reflective analysis of one of the most powerful philosophical and methodological programs for the development of reflective thinking in Russia. This is the “Program for the Development of Regional Social Systems by Means of Education”, developed in the 90s of the last century by a team of young scientists on the basis of the theory of developing education of V.V. Davydov. The author studies the problems to be solved by the program as well as the (...) main stages of its implementation. Such projects as “Metropolitan Education”, “Updating the content of education: meta-subjects, meta-subject technologies”, “Education of design activities: School of General Designers”, – are in the centre of analysis. The author discusses also the structures of solutions that have been aimed at the developing educational practices (experimental sites, innovative networks) and reflective thinking in the metropolitan education system (Expert Council). The results of the implementation of the program at each stage are summed up. The limitations in the application of the reflection method are analyzed and the path of further research is outlined. (shrink)

Filosofisk værk om kærlighed med udgangpunkt i personalismen.

En la actualidad existe amplia evidencia acerca de la variación alofónica del fonema /tʃ/ en el español de Chile asociada a factores socioculturales; sin embargo, estas investigaciones se han focalizado en la población adulta. Considerando lo anterior, la presente investigación tuvo por objetivo analizar la articulación del fonema /tʃ/ en una muestra de 161 niños/as desde los 2,0 a los 3,11 años de edad residentes de la ciudad de Temuco. La muestra fue dividida según edad y NSE. Entre los principales (...) resultados se observó variabilidad entre los grupos analizados según el cruce de las variables edad y NSE. En cuanto a la variación alofónica del fonema /tʃ/ según el NSE, también se evidenció un comportamiento variable entre los grupos analizados. Los resultados de esta investigación concuerdan con las discusiones actuales respecto de la relación entre los procesos evolutivos propios de la adquisición y la emergencia de variaciones de tipo social. (shrink)

Cette étude vise à identifier les facteurs associés à l’insatisfaction des jeunes adultes finlandais qui présentent une incapacité physique majeure, avec ou sans déficience intellectuelle concomitante, à la suite de leur transition des services santé pour enfants aux services pour adultes. Les pédiatres neurologues ont utilisé la grille d’évaluation clinique du Système de classification de la fonction motrice globale (étendu et révisé) de niveau IV ou V afin de diagnostiquer l’incapacité physique majeure spécifique à chacun des 74 participants (âge moyen (...) : 20,2 ans). Trente-neuf (53%) participants présentaient une déficience intellectuelle concomitante, selon la CIM-10 (QI inférieur à 70). Les pédiatres neurologues ont développé l’instrument Severely Disabled Youths’ Life Situation and the Functioning of the Service Systems in Finland afin de recueillir et traiter les données. Enfin, les tests de Fisher examinaient les corrélations entre l’insatisfaction des facteurs de soins et les soins de santé. Des régressions logistiques binaires ont permis d’associer l’insatisfaction à l’égard des services santé à la nécessité d’utiliser de nouveaux appareils d’assistance, à la difficulté accrue d’accéder à des rendez-vous médicaux et à l’ignorance des médecins à l’égard des problématiques du handicap. L’étude recommande la création de cliniques neurologiques multi-professionnelles qui accueilleraient les jeunes adultes qui présentent des incapacités physiques majeures, avec ou sans déficience intellectuelle, et qui initieraient les médecins aux caractéristiques de ces catégories de patients et à leurs enjeux spécifiques. (shrink)

Fredrikzon in Haffenden (2023) trdita, da je tako imenovani koncept izbrisa ostal v veliki meri neraziskan. Toda kaj pomeni izbris – kako deluje in kako se reproducira, zlasti v povezavi z globalnim kapitalizmom? V nasprotju z individualizacijo represivnega značaja izbrisa, si ta tekst prizadeva tematizirati izbris kot konstitutivni mehanizem globalnega kapitalizma, ki prežema njegovo logiko. Izhajajoč iz različnih disciplinarnih področij, bo ta raziskava tematizirala izbris kot pojem, ki ni izoliran, temveč povezan z njegovimi političnimi, družbenimi, kulturnimi, fizičnimi in tehnološkimi dimenzijami (...) ter procesi, ki mu dajejo pomen znotraj časovnega horizonta. Osrednja teza tega prispevka bo torej, da je treba proces izbrisa razumeti kot bistveni element modernosti, ki se neizprosno pojavlja v njeni zgodovini in zlasti v sodobni politiki. (shrink)

MARKOVIČ, P. : Slovenský literárny klasicizmus a preromantizmus. Prešov : Vydavateľstvo Prešovskej univerzity v Prešove, 144 s. ISBN 978-80-555-2496-2.

InhaltVorwort SiglenverzeichnisWerner Beierwaltes: Zum Tode von Reinhard Lauth am 23. August 2007 Marco Ivaldo: Nachruf auf Reinhard Lauth Wilhelm Lütterfelds: »Ich allein aber verstehe es recht.« Fichtes idealistischer Verstehensbegriff und seine Paradoxie Jean-François Goubet: Über die akademische Freiheit. Analyse eines sittlich, rechtlich und philosophisch grundlegenden Begriffs in Bezug auf Fichtes Antrittsrede zum Rektorenamt im Jahre 1811 Marco Rampazzo Bazzan: Idee und Gesicht in den Fünf Vorlesungen über die Bestimmung des Gelehrten Nina W. Gromyko: Das Transzendieren als grundlegende anthropologische Konstruktion (...) in Fichtes Vorlesungen über die Bestimmung des Gelehrten Valérie Kokoszka: L’Affektenlehre dans la dernière philosophie de Fichte Kaoru Hoshiba: Das Problem der Sprache bei Fichte Martin Siegel: Die Einforderung eines lebendigen Sprachvollzugs als Kennzeichen der späten Wissenschaftslehren FichtesRainer Adolphi: Die Tatsachen der Tathandlung. Über Fichtes implizite Auseinandersetzung mit den Anfängen einer ›anthropologischen‹ Depotenzierung der Vernunft Marina Bykova: Fichte’s Doctrine of the Self-Positing Subject Alexander Kudrjaschew: Die Entfaltung des Fichteschen Erfahrungsgrundes Peter L. Oesterreich: Fichte und die Kunst des PhilosophierensGiorgia Cecchinato: Fichtes Ästhetik. Eigene Reflexionen über Kunst und WissenschaftslehreManuel Jiménez Redondo: Die unzeitgemäße Aktualität Fichtes, aufgezeigt am Beispiel der Beziehung der theoretischen und praktischen Philosophie in seinem SpätwerkFranck Fischbach: De l’acte à l’être: la dernière philosophie de Fichte Marco Ivaldo: Sittlicher »Begriff« als wirklichkeitsbildendes Prinzip in der späten Sittenlehre Katja V. Taver: Interpersonalität. Von den Wolfskindern zu den Thatsachen des Bewusstseyns von 1810/11Ulrich Fritz Wodarzik: Prinzip Liebe – zwischen Natur und Freiheit beim späten FichteAlois K. Soller: Keine moralische Selbstbestimmung im Spätwerk Fichtes. Zur Genese eines VernunftdeterminismusJean-Marie Vaysse: Fichte, penseur de l’actualité. (shrink)

Machine generated contents note: -- Introduction to the OneThe Concept of One: From Philosophy to Politics -Artemy Magun Part I. Metaphysics of the One and the Multiple1. More than One -Jean Luc Nancy 2. Condivision, or Towards a Non- communitarian Concatenation of Singularities -Gerald Raunig 3. Unity and Solitude -Artemy Magun 4. The Fragility of the One -Maria Calvacante 5. The One: Construction or Event? For a Politics of Becoming -Boyan Mancher Part II. 20th-Century Thinkers of Unity and Multiplicity 6. (...) Truth and Infinity in Badiou and Heidegger -Alexey Chernyakov 7. Complicated Presence: The Unity of Being in Parmenides and Heidegger -Jussi Bachman 8. The Universal, the General, the Multiple in the Perspective of a Political Utopia: Deleuze and Badiou on the Event -Keti Chukhrov 9. Humanity, Unity and the One -Nina Power Part III. Unity and Multiplicity in Nature 10. Elemental Nature as the Ultimate Common Ground of the World Community -Susanna Lindberg 11. Vegetative Democracy, or the Post-metaphysics of Plants -Michael Marder Part IV. Unity in Action: Forms of Political Consolidation in the Case of Contemporary Russia12. Collectivity in Post-revolutionary Russia -Igor Tchubarov13. Street University: Production of Collective Time and Public Space -Pavel Arsenyev 14. Fighting Together: the Problem of Solidarity -Carine Cle;ment Part V. E Pluribus Unum: Res Publica and Community 5. How Does One Constitute the One? Theology of the Icon, Theory of Non-representative Art and of Non-representative Politics -Oleg Kharkhodin 12. Drawing Lots in Politics: Unity and Totality -Yves Sintomer. (shrink)

In the theses published in Voprosy filosofii there is, in my view, one very important question: What changes have occurred in the relations between art and science? Inasmuch as I am a scholar of foreign cultures, permit me to express that question a bit more concretely for myself: What changes have occurred in the West in the interactions between art and science? The question is rather complex, for in responding to it one must always take into consideration the factor of (...) "compression of time" during the RST. Not only scientific discoveries and industrial equipment have begun to obsolesce rapidly but also the notion of the role of science in the social and cultural development of society. Regrettably, the authors of some works published in our country, even in the 1970s, analyzing the relationship between science and art that has come into being in the West, ignore this circumstance. The "ancient" debate between Snow and Leavis, now almost fifteen years in the past, is presented as the most recent stirring in contemporary bourgeois culture. Yet even at that time it was clear that these discussions were to no point and would not lead to a constructive solution of the conflict between the "two cultures": the contradictions had gone entirely too far. Even then the English poet Auden granted that when he encountered scientists he felt like a "shabby scribe who had accidentally entered a drawing room bulging with dukes." This was not any rank-and-file "lyricist," but the famous Auden himself'. (shrink)

The relevance of the research is that the information and computer communications of scientific and educational activity as a factor of the development of the information society are analyzed. Statement of the task - the modern stage of the socio-political development of Ukraine is characterized by the unprecedented pace of development of a new information and communication arrangement of scientific and educational activities in society and, as a result, its development as informational and civic. Object of research - information and (...) computer communications of scientific and educational activity as a complex social, cultural and economic phenomenon. The subject of research is the influence of the information society on the development of information and computer communication of scientific and educational activities. Analysis of recent publications and research. The author focuses on the analysis of the problems of the informational society, which was investigated in the works of I. Wallerstain, Z.Bzhezynsky, D. Bell, J.Gelbreyt, P.Drucker, A.Lazarevich, A.Porter, O.Toffler, and R.Hatcheson, as well as in the works of domestic scientists - V. Andrushchenko, V.Voronkova, O.Kivlyuk, M.Kyrychenko, A.Punchenko, D.Sviridenko. Selection of unexplored parts of the general problem. Unsolved earlier part of the general problem. Setting objectives. Representatives of the modern scientific and educational environment did not notice in due time that with the advent of the computer in the world fundamental concepts of education, man, science, the Universe, temporal measurements of time, tendencies of the development of the modern world have changed significantly. Education determines the pace of world development, and the ownership of its markets began an unprecedented rigorous competition. Information and knowledge have become a tremendous wealth, an intangible asset to the development of nations and states. Methodology of the research - the use of synergistic and axiological methods that contribute to deep penetration into the essence of the object and subject of research. Scientific novelty of the research. This scientific study involves addressing the socio-philosophical meaning of the concept of information and computer communications of scientific and educational activity as a factor in the development of the information society. Presenting the main material : the problems concerning the global informatization of the society that stimulated all processes of international cooperation of people have been revealed; due to the development of the information and communication sphere, the needs of management systems of the states, societies and their citizens in various informational services have been determined, radical changes in all security systems of socio-political relations; the historical tendency of development of industrial, then - postindustrial and informational society on the basis of the concept of J.Masuda is analyzed; it was disclosed that the progress of the information and education problem requires us to improve considerably the educational information and communication systems and technologies of education; the directions of improvement of information and computer communications of scientific and educational activity as the factor of development of the information society are substantiated. Conclusions - the concept of information and computer communications of scientific and educational activity as a factor of development of the information society is formed. The result of the research is the development of the directions of reforming the education system in Ukraine and the use of concepts for the introduction of computer information and communication technologies for these purposes. (shrink)